Orthobiologics Revisited: A Concise Perspective on Regenerative Orthopedics

orthobiologics stem cells growth factors regenerative medicine tissue regeneration

Authors

  • Fábio Ramos Costa Department of Orthopedics, FC Sports Traumatology, Salvador 40296-210, BA, Brazil., Brazil
  • Luyddy Pires Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil. Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Brazil
  • Rubens Andrade Martins Medical School, Tiradentes University Center, Maceió 57038-000, AL, Brazil., Brazil
  • Márcia Santos Nutritional Sciences, Metropolitan Union of Education and Culture, Salvador 42700-000, Brazil., Brazil
  • Gabriel Silva Santos Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil. Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Brazil
  • João Vitor Lana Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil., Brazil
  • Bruno Ramos Costa Medical School, Zarns College, Salvador 41720-200, BA, Brazil., Brazil
  • Napoliane Santos Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil. Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Brazil
  • Alex Pontes de Macedo Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil. Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Brazil
  • André Kruel Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil., Brazil
  • José Fábio Lana Department of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, Brazil. Regenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, Brazil. Medical School, Max Planck University Center (UniMAX), Indaiatuba 13343-060, SP, Brazil. Clinical Research, Anna Vitória Lana Institute (IAVL), Indaiatuba 13334-170, SP, Brazil. Medical School, Jaguariúna University Center (UniFAJ), Jaguariúna 13911-094, SP, Brazil., Brazil
Volume 2024
Research Article
December 30, 2024

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At the forefront of regenerative medicine, orthobiologics represent a spectrum of biological substances that offer promising alternatives for tissue repair and regeneration. Traditional surgical treatments often involve significant risks, extended recovery periods, and may not fully restore tissue functionality, creating a strong demand for less invasive options. This paper presents a concise overview of orthobiologics, reexamining their role within the broader landscape of regenerative medicine. Beginning with a brief introduction to orthobiologics, the paper navigates through various types of biological materials, their associated mechanisms of action and clinical applications.

By highlighting platelet derivatives, bone marrow-derived products, and processed adipose tissue, among others, it underscores the pivotal role of orthobiologics in prompting biological responses like cellular proliferation, differentiation, and angiogenesis, thereby fostering tissue healing. Furthermore, the paper explores the diverse applications of orthobiologics in orthopedic conditions, outlining their utility in the treatment of bone and soft-tissue injuries. Addressing clinical considerations, it discusses safety profiles, efficacy, patient selection criteria, and emerging challenges. With the limitations of traditional medicine becoming more apparent, orthobiologics offer an innovative and less invasive approach to patient care.

Looking forward, the paper approaches future directions in orthobiologics research, emphasizing the need for continued innovation and exploration. Through a concise perspective, this paper aims to provide clinicians, researchers, and stakeholders with a comprehensive understanding of orthobiologics and their evolving role in regenerative medicine.