Emerging Medicine and Public Health (ISSN : 3023-3305) is a peer-reviewed, open-access journal dedicated to advancing the fields of medicine and public health. Our mission is to provide a platform for researchers, healthcare professionals, and policymakers to share their groundbreaking research and insights, contributing to the collective knowledge and the well-being of global populations. our journal is committed to fostering innovation in both medical science and the broader public health arena.
Acknowledgment to Reviewers of Emerging Medicine and Public Health in 2024
The editors of the Emerging Medicine and Public Health would like to thank our many reviewers and guest editors for their diligent efforts that have enabled us to bring quality content to our readers. We greatly appreciate our reviewers for taking time to serve the journal during these trying times.
Copyright (c) 2024 Publications by EMPH Editorial Office (Author) https://creativecommons.org/licenses/by/4.0
Effects of Hydroethanolic Leaf Extract of Datura Metel on the Hippocampus and Cerebellar Cortex of Adult Sprague Dawle Rats
Background: Datura metel is a plant of medical importance, often abused due to its psychostimulatory properties. Its use to relieve flu symptoms has led to an upsurge in consumption. Aim: To evaluate the impact of Datura metel leaf extracts on the histology and histochemistry of the brain. Materials and Methods: Five groups, A, B, C, D, and E, each having five adult rats, were formed out of 25 rats in total. Group C, D, and E were treated with hydroethanolic leaf extracts of 150mg/kg, 300mg/kg, and 600mg/kg body weight respectively. Whereas, group A served as the negative control and group B as the positive control. The methodology included biochemical analysis on antioxidants enzymes and lipid peroxidation. Also, haematoxylin and eosin stain was used to examine the general tissue morphology. Additionally, neurospecific enolase (NSE) and neurofilaments proteins (NFP) were used to evaluate the neurohistochemistry. Results: Exposure to hydroethanolic extracts of Datura metel significantly increased SOD and GST (p= 0.042 and 0.003). However, there was no significant increase in catalase and MDA after 14 days of exposure. Qualitatively, neuronal degenerations in adult rats confirmed the neurotoxicity of Datura metel. Conclusion: The hippocampus, and cerebellar cortex showed neurodegenerative signs including diminished neuronal cells, dendritic arborisation, vacuolation, increased neurofilament proteins and neuro-enolase enzymes. Therefore, people should be well guided on using the plant, especially given the negative effect on the brain as shown in experimental animals used in this study.
Copyright (c) 2025 God’sman C. Eberechukwu, Oboma Y. Ibor, Tatfeng Y. Mirabeau (Author) https://creativecommons.org/licenses/by/4.0
Twin For Bad, Pericardial Effusion and Cardiac Tamponade, A Dangerous Combination
Pericardial effusion and cardiac tamponade represent a continuum of potentially life-threatening cardiac emergencies, often presenting with subtle or non-specific clinical features. This article presents a case of subacute, occult cardiac tamponade in a 56-year-old male, incidentally, discovered during cardiology follow-up. Despite a large volume of pericardial fluid, the patient remained asymptomatic due to gradual accumulation, allowing pericardial stretch. He underwent successful pericardiocentesis and stabilization. The article discusses the diverse etiologies, pathophysiology, diagnostic modalities, and therapeutic strategies for managing pericardial effusion and tamponade. Timely diagnosis, high clinical suspicion, and appropriate intervention are crucial for optimal outcomes, particularly in atypical or occult presentations.
Copyright (c) 2025 Awanwosa Valentine Agho, MD (Author) https://creativecommons.org/licenses/by/4.0
Orthobiologics Revisited: A Concise Perspective on Regenerative Orthopedics
At the forefront of regenerative medicine, orthobiologics represent a spectrum of biological substances that offer promising alternatives for tissue repair and regeneration. Traditional surgical treatments often involve significant risks, extended recovery periods, and may not fully restore tissue functionality, creating a strong demand for less invasive options. This paper presents a concise overview of orthobiologics, reexamining their role within the broader landscape of regenerative medicine. Beginning with a brief introduction to orthobiologics, the paper navigates through various types of biological materials, their associated mechanisms of action and clinical applications. By highlighting platelet derivatives, bone marrow-derived products, and processed adipose tissue, among others, it underscores the pivotal role of orthobiologics in prompting biological responses like cellular proliferation, differentiation, and angiogenesis, thereby fostering tissue healing. Furthermore, the paper explores the diverse applications of orthobiologics in orthopedic conditions, outlining their utility in the treatment of bone and soft-tissue injuries. Addressing clinical considerations, it discusses safety profiles, efficacy, patient selection criteria, and emerging challenges. With the limitations of traditional medicine becoming more apparent, orthobiologics offer an innovative and less invasive approach to patient care. Looking forward, the paper approaches future directions in orthobiologics research, emphasizing the need for continued innovation and exploration. Through a concise perspective, this paper aims to provide clinicians, researchers, and stakeholders with a comprehensive understanding of orthobiologics and their evolving role in regenerative medicine.
Copyright (c) 2024 Fábio Ramos Costa, Luyddy Pires, Rubens Andrade Martins, Márcia Santos, Gabriel Silva Santos, João Vitor Lana, Bruno Ramos Costa, Napoliane Santos, Alex Pontes de Macedo, André Kruel, José Fábio Lana (Author) https://creativecommons.org/licenses/by/4.0
The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?
Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid matrix enriched with fibrin, leukocytes, and growth factors. These components promote tissue regeneration, angiogenesis, and anti-inflammatory responses, making i-PRF suitable for bone and cartilage repair as well as drug delivery systems. This review discusses the history, biological mechanisms, and clinical applications of i-PRF in orthopedics, highlighting its potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address the challenges and limitations of i-PRF, including drug stability, release control, and bioactive interactions, underscoring the need for further research to optimize its therapeutic efficacy.
Copyright (c) 2024 Gabriel Silva Santos (Author) https://creativecommons.org/licenses/by/4.0
Circumflex Coronary Artery Originating from the Pulmonary Artery: A Rare Clinical Entity
Pediatric coronary anomalies are relatively rare. Anomalous left coronary artery from the pulmonary artery (ALCAPA) or anomalous right coronary artery from the pulmonary artery (ARCAPA) are known anomalies. Among coronary artery anomalies, the Left Circumflex artery (LCx) is the most common abnormality, with an incidence of approximately 20 percent, and it typically originates from the Right Coronary Artery (RCA) [1]. Left circumflex artery arising from the pulmonary artery (LCx) is exceedingly rare [2,3]. In adult patients, ALCAPA has been reported to cause sudden cardiac arrest in case reports [4]. Therefore, surgical treatment of coronary anomalies should be immediately considered. A 30-year-old male patient was admitted to our clinic with complaints of palpitations and chest pain. Upon physical examination, the patient's heart exhibited hyperdynamic activity. The patient had previously undergone surgery 14 years ago for subaortic stenosis and was known to have a bicuspid aortic valve. A strong suspicion of an aortic pathology prompted us to conduct an echocardiogram, which revealed significant bicuspid aortic valve regurgitation and an ascending aorta measuring 4.7 cm. CT angiography confirmed that the LCx originated from the right pulmonary artery (Figure 1) and identified a root aneurysm in the ascending aorta, along with thickening of the aortic leaflets. As a result, a Bentall procedure and a CX anastomosis were planned. As a result, a Bentall procedure and a CX anastomosis were planned. As the surgical technique, the aortic valve was resected. Both coronary arteries were prepared as button. The Cx coronary artery arising in the right pulmonary artery was divided from the pulmonary artery. The end was clipped. The No: 27 mechanical valve was sutured into the No: 30 dacron graft. The conduit aorta with valve was anastomosed with individually pledgeted sutures. Left coronary and right coronary arteries were anastomosed to the conduit with 5/0 prolene. Distal aorta anostomosis was performed with prolene continuous suture. We present an illustrative case in Figure 1, showing the left circumflex artery arising from the right pulmonary artery in the preoperative CT angiogram of our patient. There are well-established aortic collateral circulations supplying the left circumflex artery and its branches, with blood flow directed from the left circumflex artery to the pulmonary artery. Additionally, the presence of a bicuspid aortic valve and aortic valve thickening is evident.
Copyright (c) 2025 Emre Oteyaka MD, Okan Kuguoglu MD, Irem Islek MD, Prof. Dr Cengiz Erol, Prof Dr Murat Ugurlucan, Prof Dr Halil Turkoglu (Author) https://creativecommons.org/licenses/by/4.0
Bio-implication of Environmentally Exposed Malted Product (Canned and Plastic Maltina) on Some Biochemical Indices of Albino-Rats
Environmentally exposed carbonated drinks have no biological value, rather a long-term damaging effect when accumulated in the tissues as discovered in this work. This research was carried out to investigate the biochemical effect of exposing non-alcoholic drinks to direct sunlight or adverse environmental conditions. The experimental set up was made up of maltina products consisting of the exposed (Canned and plastic) sample to sunlight for period of fifteen days alongside the unexposed sample as control. Proximate analysis was carried out on the maltina samples. Environmental exposure effect on the product was investigated on animal model experiment. Twenty-four (24) male rats of wistar strain weighing 120 - 140g divided into four (4) groups of six rats, each. Assessment of liver marker enzymatic; alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkali phosphatase (ALP); and non-enzymatic (albumin and bilirubin) parameters were investigated. The proximate analysis, vitamins and mineral evaluation showed a decrease in the protein, vitamins and calcium content upon exposure. Assessment of the liver function in rat’s serum of the experimental groups showed a significant increase (p < 0.05) in ALP, AST, ALT and bilirubin, decrease in the albumin level compared with the control unexposed maltina sample groups. The findings showed that environmentally exposed maltina elicit adverse biochemical and physical changes and therefore portends greater long term toxicological effect with deleterious action.
Copyright (c) 2024 Ahmed Mariam Glory, Olajide Joseph Eniola (Author) https://creativecommons.org/licenses/by/4.0
Molecular Aspects of Oral Pathological Lesions of Patients Infected with Corona Virus (Covid -19): A Narrative Review
The scientific community has been forced by the COVID-19 pandemic to create strong and trustworthy diagnostic techniques in order to efficiently and precisely detect the virus and stop the spread of diseases. A diverse family of enclosed single-stranded RNA viruses is represented by coronaviruses (CoVs). These infections cause illnesses that impact the neurological, gastrointestinal, hepatic, and respiratory systems in humans and other animal species. However, the exact processes by which it is transmitted to people are still unknown. As implied by the nomenclature, the Middle East has a comparatively greater frequency of this disease than other parts of the world. Although they are less likely to suffer from severe disease, children are just as likely as adults to get infected with the virus. Aim of review: In light of the COVID-19 epidemic, this narrative review highlighted the vital need of laboratory diagnoses. Materials: relevant articles which obtained from various sources, including electronic databases such as PubMed, PMICD, WILEY library, the Elsevier library, and Science Direct, as well as through manual searches of relevant articles. Conclusion: According to recent empirical studies, the mouth cavity may play a crucial role in the entrance and spread of the SARS-CoV-2 virus in addition to being a site for the disease's clinical manifestation.
Copyright (c) 2025 Doaa AM Esmaeil, Somaia A Ghobar (Author) https://creativecommons.org/licenses/by/4.0
Antioxidant Therapy in Chronic Obstructive Pulmonary Disease
Objective: Chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. We aimed to evaluate the effect of antioxidant therapy on malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), total antioxidant capacity (TAC), and nitric oxide (NO) levels, as well as on pulmonary functions and arterial blood gases in COPD. Design: Prospective clinical study. Subjects/Patients: Twenty stable COPD patients with no comorbidities. Methods: Pulmonary functions, arterial blood gases, MDA, SOD, GSH, TAC, and NO levels were measured at baseline. After 6 weeks of treatment with an antioxidant preparation consisting of vitamins A, C, E, zinc, copper, selenium, and manganese, the tests were repeated. Results: Five patients were excluded due to exacerbations and one due to anemia. In the remaining patients, MDA levels decreased, while SOD and TAC levels increased compared to baseline. No significant changes were observed in GSH and NO levels. Pulmonary function tests improved, whereas no significant differences were found in arterial blood gases. No significant correlations were observed between pulmonary function or arterial blood gases and the biomarkers (MDA, SOD, GSH, TAC, and NO). Conclusion: Adding antioxidants to the standard treatment for COPD may help restore the oxidant-antioxidant balance, which is disrupted in favor of oxidants in COPD.
Copyright (c) 2025 Ilkay Keskinel, MD, PhD, Nurhayat Yıldırım, MD (Author) https://creativecommons.org/licenses/by/4.0
The Effectiveness of Using Electronic Medical Records for Disease Registries in Saudi Arabia: A Systematic Review
Background: Disease registries are essential in healthcare systems because they make gathering, analyzing, and managing patient data for specific diseases or disorders easier. The introduction of electronic medical records (EMRs) has transformed how healthcare information is captured, stored, and shared. This study looks into the efficacy of EMRs for disease registries, focusing on the benefits, obstacles, and possible results of their use. Methods: A thorough systematic review was undertaken to assess the usefulness of EMRs for illness registries, which included papers, publications, and reports from various scholarly sources and healthcare databases. The study provides numerous critical findings that shed light on the benefits and drawbacks of using EMRs in disease registries. Results: The use of EMRs in illness registries has various advantages. The electronic format improves data quality and completeness by decreasing human and transcription errors frequent in paper-based systems. EMRs also make data collecting, integration, and sharing more efficient among healthcare practitioners, academics, and public health authorities, fostering collaboration and supporting evidence-based practices. Furthermore, EMRs provide real-time data processing and reporting, allowing for the early detection of illness patterns, the monitoring of patient outcomes, and the evaluation of treatment efficacy. Conclusion: When deploying EMRs for illness registries, however, numerous issues must be considered. Because of the sensitivity of patient health information, privacy, and security concerns emerge as important factors. To protect patient confidentiality, adequate precautions such as robust data encryption, access restrictions, and specific privacy rules must be in place. Furthermore, standardization of data items and coding methods across various healthcare systems and organizations is essential for easy data interchange and interoperability.
Copyright (c) 2025 Abdullah Saad Alqahtani, Dr. Salah Alshagrawi (Author) https://creativecommons.org/licenses/by/4.0
Factors within the Primary Health Care System Affecting Compliance with Standard Infection Prevention Precautions among Community Health Practitioners in Bayelsa State, Nigeria
Background: The cross-sectional study explored factors in the primary healthcare system affecting compliance with infection prevention precautions among community health practitioners (CHPs) in Bayelsa State, Nigeria, and the lived experiences of healthcare managers and practitioners in the primary healthcare system. Methods: The study involved 389 CHPs recruited through multistage sampling techniques. Data was collected using a mixed method techniques involving questionnaires, focus group discussions, and Key information interviews. However, 354 (91%) questionnaires were correctly filled out and returned. Item Mean Analysis was used to analyze data with a 2.0 criterion mean to determine factors affecting compliance with standard infection prevention precautions. Any item mean that is less than the criterion mean affects compliance with infection prevention precautions. Results: The study found that a significant proportion of CHPs (139, 39.3%) are aged 48 and above, with a 'mean age' of 42 (SD = 11.3). The majority were male (217; 85%), married (190; 54%), Christian (345; 96.8%), and had served for 21-30 years (119;37%). The study identified key factors of the primary health care system affecting compliance with standard infection prevention precautions, including the unavailability of resources (1.2), lack of infection prevention training (1.0), and absence of policy enforcement (1.0). Conclusion: The findings of this study underscore the crucial role of policymakers and government officials in addressing the factors affecting compliance with infection prevention precautions. They should commit to infection prevention by providing resources, support, and responsible personnel for overseeing and enforcing measures at the primary health centers.
Copyright (c) 2025 Doris Atibinye Dotimi, Joel Usen Silas, Yohanna Wamanyi (Author) https://creativecommons.org/licenses/by/4.0
Impact of Dance-Based Interventions on Respiratory Health and Anthropometric Parameters in Healthy Adults
The study examined the impact of dancing exercise on pulmonary function and anthropometric parameters in 40 male and female adults. Participants were divided into pre-dancing and post-dancing groups. The study found that after 4 weeks of exercise, both genders experienced improved pulmonary function and anthropometric parameters (p < 0.05). After post-dancing exercise, male adults had a significant increase in FEV1 (5.5 {plus minus} 1.9%) and FVC (5.2 {plus minus} 1.7%), compared to pre-dancing exercise levels (FEV1 3.5 {plus minus} 0.2%, FVC 3.3 {plus minus} 0.5%). Female adults had an increase in FVC (4.3 {plus minus} 2.1%) and PEF (9.2 {plus minus} 1.9%) compared to pre-exercise levels (FVC 2.9 {plus minus} 2.1%, PEF 7.6 {plus minus} 0.8%). After dancing exercise, male adults had a decrease in weight (62 {plus minus} 0.6 kg) and BMI (22 {plus minus} 0.9 kg/m2) when compared to pre-dancing exercise. Female adults experienced a decrease in weight (54 {plus minus} 0.8 kg) and BMI (25 {plus minus} 0.6 kg/m2) when compared to pre-exercise measurements of (60 {plus minus} 0.7 kg) and BMI (21 {plus minus} 0.9 kg/m2). Dancing exercises led to improved anthropometric parameters for both male and female adults. A Pearson correlation analysis showed a significant, positive correlation between BMI and the ratio of FEVI to FVC for both genders (p<0.05 & p<0.01). Dancing significantly improves oxygen saturation levels in both male and female participants, indicating that physical activity enhances respiratory efficiency and oxygen delivery. The study reveals that dancing exercise improved pulmonary function in healthy adults, with significant improvements in BMI and respiratory measures, suggesting its potential for optimizing pulmonary function.
Copyright (c) 2025 Arientare Rume Rotu, Mega Obukohwo Oyovwi, Ejayeta Jeroh, Kehinde Henrietta Babawale, Ngozichika Obiageli Keke, Anthonia Oguguo Confidence Onyenwenyi (Author) https://creativecommons.org/licenses/by/4.0
Nutrition and Wellness for Teenage Girls: Supporting Development, Hormonal Balance, and Mental Resilience
It is also important to note that adolescents are the developmental stage that is significantly important for the physical, emotional, and cognitive changes. To the young girls of preteen and teenagers, food is central in managing hormonal swings, moods, and handling the change milestones in their lives. Stressors like school transitions, family difficulties, or moving may find policies that interfere with regular and positive mood, however nutrition and self-care might reduce these effects. This theoretical and research-based article synthesizes data obtained from scientific research, cases and practical recommendations aimed to help teen-age girls successfully endure these remarkable years.
Copyright (c) 2025 Sabira Arefin, Global Health Institute Research Team, Dr. Hussam Muhy Abady Al Alwany (Author) https://creativecommons.org/licenses/by/4.0
Child Nutrition and Mental Health: Parental Guidelines for Balanced Development
Roles of cardinal nutrients in relation to physical, cognitive, and emotional development during childhood. New information shows that essential nutrition is crucial for the health of a patient’s mind and that proper nutrition can help with such diagnoses as ADHD, anxiety, and depression. In this article, specific recommendations as to diet and nutrition for kids are provided to help parents avoid the problem of imbalance and avoid or minimize the use of medication. Based on the findings and various successful examples described in the text, these recommendations are designed to provide families with advice on how to promote health and develop the best mental self in children.
Global Health Institute Research Team Global Health Institute Research Team
Accelerating Drug Discovery Pipelines with Big Data and Distributed Computing: Applications in Precision Medicine
The convergence of big data and distributed computing technologies is revolutionizing the drug discovery process, enabling faster and more precise development of therapeutic solutions. This paper explores how these advanced technologies accelerate drug discovery pipelines, with a focus on their applications in precision medicine. Traditional drug discovery approaches often involve long timelines, high costs, and limited scalability. Big data, derived from genomic, proteomic, clinical, and real-world data sources, has become a cornerstone for modern drug discovery, providing vast insights into complex biological systems and disease mechanisms. However, the volume and complexity of these datasets necessitate robust computational solutions. Distributed computing frameworks, including cloud computing, grid systems, and GPU-accelerated platforms, address these challenges by offering high-throughput data processing and scalable infrastructure. These tools empower researchers to perform tasks such as virtual screening, biomarker identification, and drug repurposing at unprecedented speeds. The integration of big data with distributed computing has been particularly transformative in precision medicine, enabling the tailoring of treatments to individual genetic and phenotypic profiles. This paper delves into case studies highlighting the successful application of these technologies in drug discovery, such as identifying novel biomarkers and expediting preclinical drug candidate evaluation. It also addresses ethical considerations, including data privacy and equitable access to personalized therapies. Finally, the paper outlines the future potential of these technologies, emphasizing their role in reshaping healthcare and delivering more effective, patient-centered solutions. By harnessing the synergy of big data and distributed computing, the pharmaceutical industry can overcome traditional bottlenecks, paving the way for innovative, cost-effective, and time-efficient approaches to drug discovery and development.
Copyright (c) 2024 Ahmed Elgalb (Author) https://creativecommons.org/licenses/by/4.0
Hematological Measurements in Mice after Injection with B. Subtilis Extract
A number of special blood parameters (red blood cells, white blood cells, and platelets) were studied in the blood of mice exposed to the effect of organic extract of B. subtilis because it is rich in chemical compounds and is more effective against gram-negative and gram-positive bacteria. The recorded results are shown in Table (1). The hematological parameters of the blood of mice when treated with bacterial extract of B. subtilis at the rate of ml (5) per 1 kg of weight of mice decreased in relation to red blood cell count (R.B.C), platelet count (PLT). While the number of white blood cells (W.B.C) increased after one day of injection compared to the control group, it was observed that the blood parameters of the mice returned to their normal limits after a week of treating the mice with the bacterial extract compared to the control group.
Copyright (c) 2023 Dr. Rami Hammod https://creativecommons.org/licenses/by/4.0
Acknowledgment to Reviewers of Emerging Medicine and Public Health in 2023
Copyright (c) 2023 Publications Editorial Office (Author) https://creativecommons.org/licenses/by/4.0